Regulation of bone resorption and formation in health and disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/345401

Funding Status
Closed

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Funded Activity Summary

Bone is continually being formed and broken down, and these two processes are critical forthe maintenance of a normal skeleton. These processes are dependent upon communication between the bone building and degrading cells, and the hormones growth factors and cytokines that are present in the circulation or produced in bone. The tightly regulated processes of bone formation and degradation need to remain equal, and are essential for the achievement and maintenance of skeletal strength and form. Osteoporosis results from an excess of bone breakdown over formation, and our Program aims to identify the factors that regulate these processes, and develop new therapies that can modify them. We will also determine what it is about bone cell properties that make some cancers, especially those of breast and prostate, particularly prone to spread to bone.

Funded Activity Details

Start Date: 01-01-2005

End Date: 01-01-2009

Funding Scheme: Programs

Funding Amount: $5,596,183.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Endocrinology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Coupling of bone formation to resorption | Immune cell interactions with bone cells | Mechanisms of bone metastasis | Osteoblast differentiation and bone formation | Osteoclast differentiation and bone resorption

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