Transcriptional targets of the MEN1 tumour suppressor in endocrine cancer

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/339423

Funding Status
Closed

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Funded Activity Summary

We have developed mouse models of a human cancer syndrome called multiple endocrine neoplasia type 1 (MEN 1) by inactivating the tumour suppressor gene responsible. These mice devlop tumours of a wide variety of different tissues, including the pancreas, pituitary, parathyroids and gonads. The data obtained from this project will be the first major step towards determining the mechanism by which the Men1 gene functions as a tumour suppressor and should shed light on its role in normal cell cycle regulation. Findings from murine models of endocrine cancer will lead to a better understanding of MEN 1 in particular, and also of carcinogenesis in general. Defining the cellular pathways normally disrupted by loss of the MEN 1 gene will be useful in designing therapeutic approaches to control endocrine tumours and some other types of cancer.

Funded Activity Details

Start Date: 01-01-2005

End Date: 01-01-2007

Funding Scheme: NHMRC Project Grants

Funding Amount: $454,500.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oncology and Carcinogenesis

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cancer susceptibility | differential gene expression | mouse models of cancer | multiple endocrine neoplasia | pancreatic cancer | transcriptional coregulator | transgenic and knockout mice | tumour suppressor gene

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