Insights into the acute cerebral lesion of childhood diabetes and it's neuropsychological sequelae

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/334354

Funding Status
Closed

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Funded Activity Summary

Type 1 diabetes in childhood is a major cause of morbidity with an Australian prevalence of approximately 20 per 100,000 children under 15 years of age. The leading cause of death in type 1 diabetes in children and adolescents is diabetic ketoacidosis complicated by cerebral oedema (brain swelling), the origins of which remain unknown. This research is aimed at providing an insight into changes in the brain of children with diabetic ketoacidosis (DKA) and the relationship of these brain changes to short and long term neuropsychological functioning. The major aim of this project is to provide an insight into brain changes of children with diabetic ketoacidosis (DKA) and the relationship of these brain changes to subseuqent brain function. This is a study where we will simply observe differences between newly diagnosed type 1 diabetic patients with no ktoacidosis, ketoacidosis or ketoacidosis with brain swelling over 6 months. We will measure brain function using various techniques includiung: magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), electrophysiology (EEG) and neuropsychological tests. The significance of this project is that it will provide insight into the brain impairment of diabetic patients with and without DKA, and with brain swelling in the context of DKA. By further clarifying the nature of brain impairment we will provide early intervention strategies to improve psychological development of the young patients with diabetes. In addition to this we hope to better understand the origins of brain swelling during DKA and design treatment protocols that will prevent this devastating complication.

Funded Activity Details

Start Date: 01-01-2005

End Date: 01-01-2007

Funding Scheme: NHMRC Project Grants

Funding Amount: $416,000.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Endocrinology

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Cerebral oedema | Children | Cognition | Ketoacidosis | Mortality | Neuronal biochemistry | School/academic functioning | Type 1 diabetes

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