The Role of Eph/ephrin clustering and trafficking in control of tumour cell invasion

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/334085

Funding Status
Closed

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Funded Activity Summary

Eph and ephrin proteins are important for normal development of the embryo by controlling cell positioning. In adult tissues these proteins are present at low levels but are found at high levels in human cancers, including skin cancers, where their presence is thought to promote aggressive tumours. We wish to understand how these proteins control cell movement and contribute to cancer progression so that we can develop new cancer therapies.

Funded Activity Details

Start Date: 01-01-2005

End Date: 01-01-2007

Funding Scheme: NHMRC Project Grants

Funding Amount: $439,500.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Eph receptors | cancer: mechanism of growth, invasion, metastasis | cell adhesion | leukaemia | melanoma | metastasis and invasion | metastatic progression | receptor dimerisation | receptor trafficking | therapy

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