Helix VIII of G protein coupled receptors is a lipid-activated signalling sensor

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/334049

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

G protein-coupled receptors (GPCRs) are the largest superfamily of membrane-embedded receptors and represent prime targets for drug development. The molecular basis for their activation and regulation is poorly understood, particularly the contribution of the membrane environment to receptor function. Using a range of molecular and biophysical approaches and the angiotensin receptor as a model GPCR, studies are proposed to understand the role of the cell membrane in GPCR activation. The results will provide important new information on the molecular mechanism of GPCR regulation and exciting new approaches for drug design.

Funded Activity Details

Start Date: 01-01-2005

End Date: 01-01-2007

Funding Scheme: NHMRC Project Grants

Funding Amount: $389,250.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Pharmacology and Pharmaceutical Sciences

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Angiotensin receptor | Cardiac hypertrophy | Cardiovascular disease and hypertension | Endocrine disorders | G protein coupled receptors | Membrane-mediated signalling | Molecular pharmacology | Peptide-membrane interactions | Pharmacology | Vascular regulation

Related Links