Hematopoietic cytokines for the repair of myocardial infarction

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/332503

Funding Status
Closed

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Funded Activity Summary

Heart attacks remain one of the most common causes of heart failure. Unlike many other tissues such as the skin or bone marrow, the heart is unable to repair itself following a heart attack. Recently it has been recognised that bone marrow cells can to a small degree repair the heart. How this is done is not known but it may be due to the formation of new blood vessels and perhaps new heart muscle. Unfortunately, the repair by bone marrow cells is not very efficient. One way of improving the efficiency of heart repair by bone marrow cells is to give people bone marrow growth factors that increase the number of bone marrow cells in the blood and thus, increase the number at the site of heart injury. Our preliminary research shows that this is the case although the efficiency of repair is still not enough as a useful therapy. This project will examine how bone marrow growth factors improve heart repair following heart attacks and explore ways of improving the efficiency of repair to permit trials in humans.

Funded Activity Details

Start Date: 01-01-2005

End Date: 01-01-2007

Funding Scheme: NHMRC Project Grants

Funding Amount: $334,375.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bone marrow | cell therapy | cytokine | cytokine therapy | myocardial infarction | therapeutics

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