What is the role of codon bias in HIV-1 genome?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/331300

Funding Status
Closed

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Funded Activity Summary

Both human and viral genetic materials (ribonucleic acids, RNA) are made up of 4 different basic residues, namely A, U, G and C. Combination of any three of these ribonucleic acids residues is known as codon , which is essential to target one of the twenty amino acids to the host cell machinery for the making of proteins. Eighteen out of these twenty amino acids can be represented by more than one codon during the making of proteins. Interestingly, human and viral proteins, such as HIV-1, utilise two completely different subsets of codons (codon bias) for the synthesis of their respective proteins. The objective of this proposal is to delineate the functional requirement of this codon bias in HIV-1 replication cycle. Results from this work will identify novel elements that may be used for the design of novel antiretroviral strategy. Furthermore, lesson learned from this project will also provide important clues to improve the efficacy and safety of the design of current retroviral gene delivery vector.

Funded Activity Details

Start Date: 01-01-2005

End Date: 01-01-2007

Funding Scheme: NHMRC Project Grants

Funding Amount: $341,250.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Virology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Biochemistry and Molecular Biology | Codon Usage | HIV | HIV/AIDS | Infectious Diseases | Microbiology - Virology | Protein Folding | RNA Genome | Translation

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