The Role of TGF-beta Signaling in Suppression of Stat3-mediated Tumorigenesis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/331005

Funding Status
Closed

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Funded Activity Summary

Stomach cancer is the third most prevalent cancer in the Western World and result in the yearly death of several thousand people in Australia alone. We have discovered a specifice gene mutation of a receptor molecule called gp130 that results in the formation of stomach cancer in mice. We are now aiming to understand the exact molecular events by which this mutation results in the uncontrolled growth of stomach mining cells. Our proposal combines the expertise of the two investigators in signal transduction and the making of genetically modified mouse models. These strategies will be employed to specifically address in the laboratory mouse the function of two specififc signaling cascades, called Stat3 and TGF-beta. The identification of detailed description by which these molecules causally relate to cancer formation will provide clear and specific molecular targets for future therapies to treat various cancers, including those of the stomach.

Funded Activity Details

Start Date: 01-01-2005

End Date: 01-01-2008

Funding Scheme: NHMRC Project Grants

Funding Amount: $667,000.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Cancer | Cancer diagnosis | Gastric tumor | Stat3 oncogene | TGF-beta signaling | cancer treatment | kockout mice | tumor suppressor | tumorigenesis

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