Mechanistic studies of c-Cbl - a modulator of energy homeostasis.

Funded Activity Summary

Obesity has become one of the most serious health care problems in the world. It is a problem not just because more people are getting fatter. It is a problem because obesity is a major risk factor for many other diseases including Type 2 diabetes and heart disease. While many consider the solution to be straight forward, ie eat less, this is obviously not an effective solution because the problem is accelerating at lightning speed around the world. At the Garvan Institute we have recently identified a new mouse model bearing a disruption in one single gene. This mouse eats 30% more food than its siblings but has half the body fat. This exciting discovery constitutes the foundation for the present proposal.

Funded Activity Details

Start Date: 01-01-2005

End Date: 01-01-2007

Funding Scheme: NHMRC Project Grants

Funding Amount: $454,500.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

body weight regulation | diabetes mellitus | energy expenditure | glucose metabolism | insulin resistance | intracellular signal transduction | lipid metabolism | metabolic syndrome | obesity | ubiquitin

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