Development and pre-clinical evaluation of G-DSF inhibitors for inflammatory joint disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/305558

Funding Status
Closed

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Funded Activity Summary

G-CSF was originally identified as a cytokine regulating the production of neutrophils and haemopoietic stem cells from the bone marrow and it is currently used clinically for these properties in bone marrow transplant patients around the world. Anti-cytokine therapy with TNF blockade has recently been introduced for the treatment of rheumatoid arthritis. However, not all patients respond to TNF inhibition. We have gathered extensive data which shows that G-CSF also promotes inflammation in experimental models of inflammatory joint disease. We propose to develop inhibitors of G-CSF as a novel form of anti-cytokine therapy for inflammatory joint disorders, such as rheumatoid arthritis.

Funded Activity Details

Start Date: 01-01-2005

End Date: 01-01-2005

Funding Scheme: NHMRC Development Grants

Funding Amount: $88,329.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Rheumatology and Arthritis

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

animal model | colony stimulating factors | cytokine regulation | rheumatoid arthritis

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