Regulation of the cardiac sodium/proton exchanger during ischaemia, reperfusion and preconditioning

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/302039

Funding Status
Closed

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Funded Activity Summary

Heart attacks are currently treated with drugs to dissolve the clot in the coronary artery or by catheterisation with the aim of restoring blood flow to the ischaemic heart muscle. If restoration of blood flow occurs soon after the heart attack, the ischaemic region can recover completely. However if treatment is delayed, the ischaemic region may not recover. This project concerns the mechanisms that are involved in the myocardial damage which occurs after moderate periods of ischaemia. A transport protein, the sodium-proton exchanger, is involved in recovery and if its action is blocked with an inhibitory drug, recovery of the ischaemic myocardium is improved. However clinical trials of the drug in humans have given variable results. We are investigating the regulation of this exchanger and believe that such information is essential to the efficient use of the inhibitory drugs in humans and may identify other pathways to improving recovery after ischaemia.

Funded Activity Details

Start Date: 01-01-2004

End Date: 01-01-2004

Funding Scheme: NHMRC Project Grants

Funding Amount: $101,000.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biotechnology diagnostics (incl. biosensors)

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

cardiac ischaemia | cardiac transplantation | coronary thrombosis | preconditioning | primary angioplasty | reperfusion damage | sodium/proton exchanger

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