Interaction Between Sleep Apnea and Metabolic Syndrome

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/301936

Funding Status
Closed

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Funded Activity Summary

In this proposal, we will study possible ways in which sleep disordered breathing (snoring sickness or sleep apnea) may cause or worsen metabolic syndrome. Sleep apnea is a common disorder frequently linked to metabolic syndrome. Metabolic syndrome is a cluster of health risk factors including increased risk of diabetes, high cholesterol, high blood pressure and excess fat around the abdomen. Metabolic syndrome is an important cause of increased death from cardiovascular disease and affects about 3 million Australians. Our theory is that lack of oxygen during sleep and disruption of normal sleep patterns leads to increased activity of the body stress handling systems and damage to the lining of the body's blood vessels. In turn, this may promote high blood fat levels and cause excess fat deposits in muscle and liver. We will measure blood, muscle and liver fat changes with treatment of sleep apnea. We believe that by damaging the lining of blood vessels, sleep apnea will also cause an inability of the body's arteries to relax properly. We will measure sleep apnea and the ability of the body's arteries to expand using novel techniques before and after treatment of sleep apnea. We will also take people off treatment to see if these changes get worse. Part of the proposal includes investigating whether snoring and lack of oxygen during sleep leads to increased blood fat levels. Finally, in another study, we will measure the change in metabolic syndrome related disorders in people with sleep apnea losing weight.

Funded Activity Details

Start Date: 01-01-2004

End Date: 01-01-2006

Funding Scheme: NHMRC Project Grants

Funding Amount: $423,650.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Respiratory Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Diabetes | Metabolic syndrome | Obesity | Sleep apnea | Sleep breathing disorders

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