Structure, function and cellular trafficking of the flavivirus NS1 protein

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/301165

Funding Status
Closed

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Funded Activity Summary

Flaviviruses are spread mainly by mosquitoes or ticks and include globally important pathogens such as yellow fever, dengue, Japanese encephalitis and West Nile. This proposal seeks to elucidate the precise function of a component of the virus ( the NS1 protein) essential for its infection cycle. We will analyse the structure and function of this protein and its role in viral disease. A complete understanding of the replication cycle of these viruses will shed further light on how they have evolved to replicate in animal cells and provide valuable information for the design of safe, new generation antiviral drugs and vaccines.

Funded Activity Details

Start Date: 01-01-2004

End Date: 01-01-2006

Funding Scheme: NHMRC Project Grants

Funding Amount: $496,500.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Applied immunology (incl. antibody engineering xenotransplantation and t-cell therapies)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

arbovirus diseases | flavivirus | molecular biology | mutagenesis | protein trafficking | vaccines | virus replication

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