The role of the TGF-b superfamily cytokine MIC-1 in the pathogenesis of atherosclerosis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/300501

Funding Status
Closed

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Funded Activity Summary

MIC-1 is a protein first cloned and characterised by our research group. It belongs to the TGF beta protein superfamily which is very important in development, cancer, wound - fracture healing and inflammation. The aim of this project was to start to gain an understanding of the role of this protein, both in normal biological processes (especially pregnancy) and in disease. MIC-1 is present in the blood of all individuals and high levels are associated with an increased risk of heart attacks and strokes. In this study we wish to use animal models, in which the gene for MIC-1 has either been deleted or enhanced, to determine whether MIIC-1 plays a direct role in these diseases.

Funded Activity Details

Start Date: 01-01-2004

End Date: 01-01-2006

Funding Scheme: NHMRC Project Grants

Funding Amount: $348,950.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutrigenomics and personalised nutrition

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

MIC-1 | animal models | atherosclerosis | cardiovascular disease | cardiovascular risk factors | cerebrovascular disease | cytokine | inflammation | monocytes

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