Molecular mechanisms underlying G protein coupled receptor signaling

Funded Activity Summary

The maintenance of optimum health and function of living cells, and consequently that of the whole organism, depends on how cells respond to a multitude of physical and chemical stimuli that continually bombard them. The majority of the chemical stimuli such as hormones and neurotransmitters impart their actions not by directly entering the cell, but instead, by binding to a specific receiver protein at the cell surface called a receptor. In one class of such receptors called G protein-coupled receptors, the transmission of the message to the interior of the cell involves yet another protein called G protein. These receptors are the most abundant type of cell surface receptors and form the targets for nearly 50% of currently used therapeutic drugs. It is, therefore, extremely important to unravel how each of these components works, and in particular to know how they work in living cells. This project utilizes state-of-the-art methodologies to examine interactions between receptors and their cognate G proteins, in living cells and in real-time. The work will answer fundamental questions about the nature of G protein-coupled receptor signaling and will aid in the future development of more effective therapeutic agents.

Funded Activity Details

Start Date: 01-01-2004

End Date: 01-01-2007

Funding Scheme: NHMRC Project Grants

Funding Amount: $596,956.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Biochemistry and molecular biology | Cardiovascular and other disease preventions | Cell signaling | G Protein-Coupled Receptors | G protein | Molecular Pharmacology | Neurological disease | Pharmacological intervention | Resonance energy transfer | Signal Transduction

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