Regulatory Dendritic Cells for the Prevention and Treatment of Graft-versus-Host Disease.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/290214

Funding Status
Closed

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Funded Activity Summary

Allogeneic bone marrow transplantation (BMT) remains the most effect curative treatment for patients with a number of malignant conditions, especially leukemia. Graft-versus-Host Disease (GVHD) ocurrs when the newly transplanted bone marrow (which includes the immune system) recognises the transplant recipient as foreign and mounts an immune attack against patient tissues. GVHD is the major complication of BMT and is responsible for the death of up to half of the patients who receive this procedure. These studies will focus on the ability of a newly defined type of white blood called a regulatory dendritic cell to prevent this complication and avoid the requirement for BMT patients to take drugs that suppress their immune system.

Funded Activity Details

Start Date: 01-01-2004

End Date: 01-01-2004

Funding Scheme: NHMRC Project Grants

Funding Amount: $165,250.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oncology And Carcinogenesis

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Bone marrow transplant | Graft versus host disease | Graft versus leukemia | Haemopoeitic stem cell transplantation | Leukemia | T lymphocytes | cytokine regulation | dendritic cell

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