The genitofemoral nerve and gubernaculum in testicular descent and inguinal hernia

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/284525

Funding Status
Closed

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Funded Activity Summary

This project examines the mechanism of descent of the testis, which when abnormal, leads to the common anomaly in infant boys of undescended testes. In addition, the tunnel through the abdominal wall which permits testicular descent very commonly fails to close afterwards, allowing the intestines to protrude through the hole to cause an inguinal hernia, which is a tender lump in the groin,and requires surgery to resolve. Our long-term aim is to understand testicular descent and inguinal closure well enough to develop non-surgical treatments for these two conditions, which are the two commonest abnormalities in children requiring surgery. We will examine how male hormones control descent of the testis indirectly by altering the anatomy and function of a specific nerve suplying the groin and scrotum. A simple and safe treatment that avoided surgery would be a major advance for infants in the developing world.

Funded Activity Details

Start Date: 01-01-2004

End Date: 01-01-2006

Funding Scheme: NHMRC Project Grants

Funding Amount: $339,750.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Paediatrics

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

calcitonin gene-related peptide | congenital anomaly of sexual development | cryptorchidism | genitofemoral nerve | gubernaculum | inguinal hernia | testicular descent

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