Differential Cooperation of MAPKs with TGF-beta signaling in Epithelial-Mesenchymal Transition

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/280913

Funding Status
Closed

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Funded Activity Summary

Tumor metastasis - the spread of tumor cells from the original site of growth to other sites in the body, is the biggest threat to survival for patients with solid tumors. The most damage change during cancer progression is the switch from a locally growing tumor to a metastastic killer. For biologist studying cancer, a major challenge is to identify the molecular and cellular mechanisms underlying the switch of non-invasive tumor to an invasive, metastatic state. This application aims to identify key molecular and cellular mechanism controlling this switch, with the ultimate aim being to devise treatments that inhibit tumor metastasis. The results from this work will provide clear and specific targets to prevent and to treat tumor metastasis. More importantly, the success of strategies used in this work can potentially be used clinically for tumor treatment.

Funded Activity Details

Start Date: 01-01-2004

End Date: 01-01-2007

Funding Scheme: NHMRC Project Grants

Funding Amount: $497,250.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry And Cell Biology Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

MAPK pathway | TGF-beta signaling | cancer | cell biology | epithelial-mesenchymal transition | fibrosis | tumor invasion and metastasis | tumor metastasis

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