The biology & therapeutic manipulation of Lymphatic vessels in cancer & lymphedema

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/280900

Funding Status
Closed

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Funded Activity Summary

This proposal brings together a team of researchers from diverse backgrounds who have already made important discoveries about the molecular control of the lymphatic system in normal physiology and cancer. The lymphatic vasculature consists of a network of vessels in organs and tissues that is critical for the regulation of tissue fluid volume and immune function. The lymphatics are also important for the metastatic spread of cancer, as they provide a route by which tumour cells spread to distant sites in the body, and for lymphedema, a condition in which lymphatic dysfunction leads to swelling of tissues. This program will explore the molecular mechanisms that control the growth and differentiation of the lymphatic vessels. It will greatly enhance our understanding of lymphatic vessel growth (lymphangiogenesis) and generate a range of reagents for stimulating or inhibiting this process. These reagents will be tested in animal models for their capacity to modulate lymphatic function in the context of cancer and lymphedema.

Funded Activity Details

Start Date: 01-01-2004

End Date: 01-01-2008

Funding Scheme: Programs

Funding Amount: $2,589,101.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry And Cell Biology Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Angiogenesis | Lymphatics | Protein tyrosine kinase | Tumor metasstases | VEGF (Vascular endothelial cell growth factor)

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