Mechanisms regulating excitation-contraction coupling in skeletal muscle

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/280623

Funding Status
Closed

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Funded Activity Summary

Muscle contraction occurs when an electrical impulse from a nerve travels over the surface of a skeletal muscle fibre and triggers the release of calcium ions from special stores inside the fibre. However, little is known about the regulatory mechanisms involved in turning on and turning off the calcium release. This project investigates the properties of the calcium release and what processes are involved in regulating it. Information about this is vital for understanding how normal muscle works and why muscles show reduced performance with exercise (muscle fatigue), with aging, and in certain diseases.

Funded Activity Details

Start Date: 01-01-2004

End Date: 01-01-2008

Funding Scheme: NHMRC Project Grants

Funding Amount: $687,750.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biotechnology diagnostics (incl. biosensors)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

exercise physiology | malignant hyperthermia | muscle contraction | muscle fatigue | muscle weakness | sarcoplasmic reticulum | skeletal muscle

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