A tyrosine phosphatase that regulates adherens junctions, cell migration and the epithelial-mesenchymal transition

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/278802

Funding Status
Closed

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Funded Activity Summary

Cell-cell adhesion which physically glues cells together to form tissues and organs, also controls processes in development, wound healing and cancer progression. I have identified a novel regulator of cell-cell adhesion that regulates cell migration and cell morphology. Since these events are crucial during metastasis (the spread of cancer) and during wound healing, understanding the function of this novel regulator may provide the basis for new approaches to developing therapeutics. Specifically, in this proposal I aim to further our understanding of the function of this novel regulator in normal physiology and to elucidate how its functions are regulated.

Funded Activity Details

Start Date: 01-01-2004

End Date: 01-01-2006

Funding Scheme: NHMRC Project Grants

Funding Amount: $496,500.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Interactions (Incl. Adhesion, Matrix, Cell Wall)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

adherens junctions | cancer | cardiovascular | cell-cell adhesion | epithelial-mesenchymal transitions | inflammation | protein localisation | tyrosine phosphatase | wound healing

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