Molecular determinants of UDP glucuronosyltransferase expression in the gastrointestinal tract

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/275545

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

The gastrointestinal tract is a major portal of entry for dietary chemicals and drugs taken orally or as suppositories. Enzymes resident in the gastrointestinal tract have an essential role in preventing these chemicals from reaching other organs and target tissues in the body and in protecting the gastrointestinal tract per se from their effects. The levels of these enzymes in the gastrointestinal tract varies quite extensively between individuals. In this project we will determine how these enzymes are regulated and what causes the large differences in their levels between individuals. This will help us to predict those individuals who are more at risk from the adverse effects of drugs taken orally or as suppositories and from the toxic effects of chemicals in the diet. The project will also help us identify therapies that can increase the levels of these protective enzymes to help reduce the effects of exposure to toxic chemicals .

Funded Activity Details

Start Date: 01-01-2004

End Date: 01-01-2006

Funding Scheme: NHMRC Project Grants

Funding Amount: $447,750.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biochemistry - lipids

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

UDP glucuronosyltransferase | chemical carcinogenesis | drug and chemical detoxification in humans | drug metabolism | gastrointestinal tract | gene regulation | polymorphisms | toxicology

Related Links