Regulation of Endothelin Converting Enzyme Subcellular Distribution and Vascular Endothelin Production.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/268913

Funding Status
Closed

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Funded Activity Summary

Endothelin is a hormone produced by the endothelial cells that line blood vessels. The role of this hormone is cause blood vessels to constrict (vasoconstriction), thus causing a rise in blood pressure. The synthesis of this hormone is crucially dependant on an enzyme that has to be located on the surface of the endothelial cell. The aim of this grant is to understqand the mechanisdms by which the location of this enzyme within the cell is regulated. The knowledge gained from this study will not only help us better understand the mechanism of endothelin production but it may also offer an insight into future therapeutic startegies to prevent the formation of endothelin, thus preventing vasoconstriction.

Funded Activity Details

Start Date: 01-01-2004

End Date: 01-01-2006

Funding Scheme: NHMRC Project Grants

Funding Amount: $399,750.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutrigenomics and personalised nutrition

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Endothelin, Endothelin Converting Enzyme Regulation | Heart Failure | Hypertension | Membrane proteins | Stroke/subarachnoid haemorrhage | Vascular Endothelial Cells | Vasoconstriction | phosphorylation

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