A single fibre study of the relationship between glucose transport and skeletal muscle contractility

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/256602

Funding Status
Closed

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Funded Activity Summary

Type 2 diabetes (a progressive disorder often accompanied by obesity) is claimed to be the most common metabolic disease in the world and is predicted to affect 1.15 million Australians by the year 2010. Muscle contraction (in the form of physical exercise or exercise training) is now an essential component in the management of type 2 diabetes and-or obesity.This project has been planned from a perspective that combines theoretical and experimental expertise in the field of muscle cell contractility with a keen interest in the role of skeletal muscle in glucose homeostasis. Work carried out within the scope of this project will contribute new insights into the pathogenesis of type 2 diabetes-obesity and new information on the cellular mechanisms involved in contraction-stimulated glucose transport by skeletal muscle. As part of this project we will develop single muscle cell-fibre preparations and appropriate protocols for monitoring cellular aspects of glucose transport in skeletal muscle. These preparations-protocols will have the potential to be used for testing anti-diabetic drugs directed towards intracellular targets. From an educational benefit point of view, the project will create the opportunity for 4-6 honours and 2-3 PhD students to acquire a rare and useful combination of skills and expertise in muscle cell biochemistry and physiology, while working on an issue of medical concern.

Funded Activity Details

Start Date: 01-01-2003

End Date: 01-01-2005

Funding Scheme: NHMRC Project Grants

Funding Amount: $284,625.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biotechnology diagnostics (incl. biosensors)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

E-C coupling | diabetes | fibre type | glucose transport | obesity | skeletal muscle contraction | type 1 diabetes | type 2 diabetes

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