Immunopathogenesis of human and murine Herpes Simplex infections

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/253684

Funding Status
Closed

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Funded Activity Summary

Herpes Simplex virus causes genital herpes, brain infections, eye infections and if passed by a mother to her infant during delivery can cause a highly damaging and sometimes lethal disease in the newborn. The virus has developed a number of strategies to overcome our immune system. The aim of this grant is to define some of these strategies in human tissue and in mice and in order to reverse them we are also defining the viral proteins which stimulate the critical immune cells . In addition we wish to understand the reasons why newborn babies have severe herpes disease compared to adults . What we learn from our experiments will assist us in developing a more effective vaccine against herpes and find new ways to treat this virus in the very young.

Funded Activity Details

Start Date: 01-01-2003

End Date: 01-01-2004

Funding Scheme: NHMRC Project Grants

Funding Amount: $315,000.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Applied immunology (incl. antibody engineering xenotransplantation and t-cell therapies)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Animal models | Congenital infection by other herpesviruses | Dendritic cells | Genital herpes | Herpes encephalitis | Herpes eye disease | Herpes simplex virus | Immunology | Neonatal herpes disease

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