Molecular characterization of E-cadherin-activated Rac signaling

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/252776

Funding Status
Closed

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Funded Activity Summary

Interactions between cells and their neighbouring cells control many important processes in the body. The adhesion molecule, E-cadherin, is a major protein that controls interactions between cells in epithelial tissues (e.g. breast, lung, gut). E-cadherin is essential for these tissues to form normally, and loss of E-cadherin function contributes to the progression of many human cancers (especially common cancers such as breast and lung). Understanding how E-cadherin controls normal epithelial cell function will therefore provide key insights into the bases for tumor progression. In this study we will examine how E-cadherin signals to the interior of cells. We have recently discovered a new signaling pathway that is turned on when E-cadherin is activated. Understanding the fundamental elements of this signaling pathway will provide invaluable insights into how cells recognize one another during health and disease.

Funded Activity Details

Start Date: 01-01-2003

End Date: 01-01-2005

Funding Scheme: NHMRC Project Grants

Funding Amount: $220,500.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Interactions (Incl. Adhesion, Matrix, Cell Wall)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Adhesion signaling | Cancer | E-cadherin | Epithelial inflammation | Gastrointestinal disease | Kidney disease | PI3-kinase | Rac | Rho-GTPases

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