Molecular studies of dentine phosphophoryn and development of a biomimetic dental restorative material.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/251707

Funding Status
Closed

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Funded Activity Summary

This project involves the study of a protein that is found in teeth and is responsible for the development of dentine. The project involves characterisation of this protein and its interaction with calcium phosphate mineral using a variety of techniques. The information obtained will allow the synthesis of a peptide that will mimick the function of phosphophoryn. This peptide will be used together with stabilized amorphous calcium phosphate in a novel dental restorative material that will help protect the surrounding tooth tissue.The outcome will be an improved understanding of the design principles used by nature to engineer teeth. The significance is the potential development of biocompatible, superior dental restorative materials.

Funded Activity Details

Start Date: 01-01-2003

End Date: 01-01-2005

Funding Scheme: NHMRC Project Grants

Funding Amount: $444,750.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical physiology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Biomineralisation | Bone and tooth abnormalaties | Bone and tooth biomaterials | Bone and tooth development | Bone and tooth regeneration | Calcium phosphate biology | Phosphoprotein | Protein conformation | Structure-function relationship

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