The effect of innate immune responses on the induction of protective immunity in murine typhoid fever

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/251695

Funding Status
Closed

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Funded Activity Summary

Salmonella are important pathogens of humans causing diseases ranging from gastroenteritis, typhoid fever to arthritis. Like most if not all infections, the early interaction between the host and the bacterium is characterised by very non-specific symptoms. These non-specific symptoms arise because the so-called innate immune system is activated by the infection. The purpose of this grant is to establish whether these non-specific symptoms, caused by the release of immunological homrones called cytokines, are essential to the development of an effective immune response which can protect against subsequent re-infection. This study has important implications for vaccines, of our understanding of how bacteria cause disease, and the role-capacity of the innate immune system in the development of immunity.

Funded Activity Details

Start Date: 01-01-2003

End Date: 01-01-2003

Funding Scheme: NHMRC Project Grants

Funding Amount: $136,500.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Salmonella | cytokines leading to effective immune induction | immunity | inflammation and adaptive immunity | innate | innate immunity

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