Cellular responses to thrombin in skeletal pathology

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/251575

Funding Status
Closed

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Funded Activity Summary

Many diseases of bones, such as osteoporosis and delayed fracture repair, result from the abnormal function of bone cells. Factors regulating bone cell function are, therefore, important in maintaining a healthy skeleton, as well as in the skeleton's response to disease. The enzyme thrombin is involved in blood coagulation but also causes bone cells to alter their behaviour. Thrombin stimulates proliferation of bone-forming cells and protects them from premature death. Thrombin also stimulates the breakdown of bone. We will investigate how thrombin's effects on bone cell behaviour influence the course of bone healing. We will also determine how thrombin stimulates bone breakdown and increases survival of bone-forming cells. This study will contribute to the understanding of how bone cells function in health and disease.

Funded Activity Details

Start Date: 01-01-2003

End Date: 01-01-2003

Funding Scheme: NHMRC Project Grants

Funding Amount: $120,775.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutritional science

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Apoptosis | Fracture repair | Inflammation | Osteoblast | Osteoclast | Osteoporosis | Protease-activated receptor | Rheumatoid arthritis | Thrombin

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