Importance of pulmonary venous electrophysiology in the development of atrial fibrillation

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/244214

Funding Status
Closed

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Funded Activity Summary

(ii) Transplant rejection can be inhibited by expression in the graft of CTLA4-Fc a reagent that blocks T cell co-stimulation enhancing allo-graft acceptance (Transplantation 2000 69:1806). High-level expression for over 100 days is expected to correlate with optimal graft acceptance. Our ability to use Kunjin to express beta galactosidase for several months in vivo without inflammation illustrates the potential for this approach (CIB ref 15). Initially we intend to use P815 cells injected i.p. into C57BL-6, where they are usually rejected within a few days. In contrast, P815 cells with Kunjin replicon-mediated CTLA4-Fc expression should survive for an extended period. Graft survival is easily monitored using FACS and anti-H-2d antibodies.

Funded Activity Details

Start Date: 01-01-2003

End Date: 01-01-2005

Funding Scheme: Early Career Fellowships

Funding Amount: $196,219.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutrigenomics and personalised nutrition

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Atrial fibrillation | Catheter ablation | Electrophysiology | Pulmonary veins | Triggers

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