Defining the role of tumour necrosis factor apoptosis inducing ligand (TRAIL) in experimental visceral leishmaniasis.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/241943

Funding Status
Closed

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Funded Activity Summary

The activation of pathogen-specific T cells by dendritic cells (DC) is a critical step in the control of most infections, as well as the success of many vaccine strategies. The specific cells and molecules involved in this process are still poorly defined. In this project, we will investigate the effects of a cell surface molecule called tumour necrosis factor related apoptosis inducing ligand (TRAIL) on the ability of DC to activate T cells during a parasitic infection caused by Leishmania donovani. By identifying the cells that express TRAIL and the effect that this molecule has on the development of immunity to pathogens, we will better understand the factors required to generate effective immune responses against infectious agents, and hence, develop better vaccines.

Funded Activity Details

Start Date: 01-01-2003

End Date: 01-01-2003

Funding Scheme: NHMRC Project Grants

Funding Amount: $153,250.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical chemistry (incl. diagnostics)

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

T lymphocyte | cellular immunity | dendritic cells | experimental pathology | immunopathology | immunoregulation | infectious diseases | natural killer cells

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