Characterisation of polymorphism in HIV-1 sequence: investigation of viral escape from HLA-restricted immune responses

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/237412

Funding Status
Closed

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Funded Activity Summary

Although drug therapy has been developed for treatment of HIV infection, there are many aspects of optimal long-term therapy that are problematic. An important reason for this is that HIV disease is different in different individuals, and we believe this is in large part attributable to the way in which the virus can escape an individual's unique immune responses against it. HIV has been shown to escape by mutating and evolving during infection, but the nature and extent to which this occurs in everyone is not established. This is an important barrier to the design of effective vaccines against HIV. This study uses a novel method to describe the ways that HIV evolves uniquely in every individual, and to determine how this information relates to subsequent disease severity, response to therapy and response to vaccination. This will allow HIV infected patients to have better 'individualised' therapy as well as help in the design of effective vaccines.

Funded Activity Details

Start Date: 01-01-2003

End Date: 01-01-2005

Funding Scheme: NHMRC Project Grants

Funding Amount: $425,250.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinimetrics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Cytotoxic T Cell | Epitope Mapping | Escape Mutants | HIV - AIDS | Human Immunodeficiency Virus Type 1 | Infectious Diseases | Major Histocompatibility Complex | Viral Infection

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