Mechanisms of immune complex-mediated inflammation in the cerebral microvasculature

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/236910

Funding Status
Closed

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Funded Activity Summary

Immune complexes are formed when an antibody binds to the molecules it is directed against. Normally, this is important for fighting infection. However in some autoimmune diseases, inappropriate formation of immune complexes can be damaging to our own tissues. This damage occurs because immune complexes attract white blood cells to the areas where they form. Many tissues can be affected by this process. However, we know very little about the effects of immune complexes specifically in the brain. This is important because immune complexes are found in the brain in diseases such as lupus. Therefore the aim of this proposal is to determine how immune complexes induce damaging inflammation in the brain.

Funded Activity Details

Start Date: 01-01-2003

End Date: 01-01-2004

Funding Scheme: NHMRC Project Grants

Funding Amount: $146,500.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Interactions (Incl. Adhesion, Matrix, Cell Wall)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

adhesion mechanisms | blood-brain barrier | cell adhesion | immune products affect the brain | inflammation | inflammatory processes of the CNS | microvascular | systemic autoimmunity | systemic lupus erythematosus

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