An X-ray crystallographic investigation into the structural basis of T-cell allorecognition

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/236825

Funding Status
Closed

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Funded Activity Summary

X-ray crystallography is an essential tool for solving the three-dimensional (3-D) structure of proteins. Proteins control the biological processes within the cell and it is the exact shape of proteins that determines how they function. Each protein is made up like a string of beads, with the building units being amino acids. Depending on the sequence of the amino acids, the protein molecule bends and forms a distinct, complex shape. This three dimensional shape allows it to specifically interact with carbohydrates, other proteins, such as enzymes or receptors, or even with molecules like DNA, to have its effect. To determine how a protein acts, it is vital to know the precise three-dimensional shape of a protein at the atomic level. This work is focused on understanding the precise shape of proteins that control the immune system. The immune system is avital process whereby individuals can fight off disease. This work will further our understanding of the immune system.

Funded Activity Details

Start Date: 01-01-2003

End Date: 01-01-2005

Funding Scheme: NHMRC Project Grants

Funding Amount: $441,000.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry And Cell Biology Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Allorecognition | Crystallization | T-cell receptor interactions | Transplant rejection | X-ray crystallography | immune system | receptor complexes

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