Members of the CMRF-35 Leukocyte Receptor Complex on Human Chromosome 17q22-24 Modulate Immune Function

Funded Activity Summary

We have identified and characterized a group of proteins on the surface of different white blood cells called the CMRF-35 molecules. We hypothesize that these molecules play a role in regulating an immune response by acting as thermostat molecules i.e. molecules able to trigger or inhibit the immune response. This project aims to define the role of two of these molecules in regulating white blood cells in their response to foreign molecules or antigens. This project will have significant impact on understanding whether these triggering and inhibitory signals initiated from the CMRF-35 molecules effects i) how the cells divide, ii) what molecules are secreted by the cells, iii) whether the cells can mature or iv) whether a cell survives or dies. Some of the molecules involved in sending these signals will be identified. The ability to trigger or inhibit cellular effects through these molecules may be important in some forms of myeloid leukemia and in the ability to help manipulate the immune response to fight tumors.

Funded Activity Details

Start Date: 01-01-2003

End Date: 01-01-2005

Funding Scheme: NHMRC Project Grants

Funding Amount: $489,750.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical chemistry (incl. diagnostics)

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Autoimmunity | Dendritic cell differentiation | Immunoregulation | Inflammation | Intracellular signaling | Leukemia | Leukocyte receptors | T cell subpopulations

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