Gene variants related to bone density and fracture.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/231421

Funding Status
Closed

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Funded Activity Summary

Bone density and osteoporosis have a genetic component. Identifying genes that are involved in determining bone density may permit advances in controlling osteoporosis. We have identified a variant that is related to bone density high enough to protect individuals four fold against Colle's fracture, the common wrist fracture seen in women. In addition, some people with bone fracture at the hip, or low bone density, have mutations in this gene. The gene is a master regulator of the cells that make bone: this gives hope that it may be possible to alter bone formation through this master regulator.

Funded Activity Details

Start Date: 01-01-2003

End Date: 01-01-2005

Funding Scheme: NHMRC Project Grants

Funding Amount: $330,375.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Rheumatology And Arthritis

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

High Bone density related gene variant | Identification of mutations related to fracture | Osteoblast differentiation factor variants and fracture | fracture | gene variant | osteoporosis

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