Muscarinic receptor signalling in the control of insulin secretion

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/230852

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

The project is aimed at a better understanding of the way in which nerves control the release of insulin from the pancreatic beta cells of the islets of Langerhans. Nerves release chemicals called neurotransmitters, one of which, acetylcholine, stimulates insulin release in conjunction with a rise in blood glucose immediately after a meal. Acetylcholine binds to receptors on the surface of the beta cells, and triggers signalling pathways inside the cell. We have discovered novel features of those signalling pathways and plan to explore them further. These include a novel route of generation of the intracellular sigalling compound, diacylglycerol, insights into the way that the intracellular messenger Ca2+ enters the cell, and a better understanding of the way in which enzymes known as protein kinases act.

Funded Activity Details

Start Date: 01-01-2003

End Date: 01-01-2005

Funding Scheme: NHMRC Project Grants

Funding Amount: $425,250.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oral implantology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

G proteins | Type 2 diabetes | insulin secretion | islet of Langerhans | muscarinic receptors | phospholipids | protein kinases | second messengers

Related Links