Regulation of mitogenic signalling via the Gab2 docking protein

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/230814

Funding Status
Closed

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Funded Activity Summary

Cell proliferation is regulated by growth factors which bind to specific receptors on the cell surface. These receptors then transmit a signal to the interior of the cell instructing it to divide. Inside the cell, the signal is transmitted by signalling proteins. Importantly, aberrant signalling by growth factor receptors or intracellular signalling molecules can contribute to cancer. We have recently demonstrated that the signalling protein Gab2 is overexpressed in a subset of breast cancers. Furthermore, we have identified that another protein, termed PKB, can 'switch off' signalling by Gab2, and that deregulated signalling by Gab2 can make cells cancerous. The aim of this project is to characterize how PKB regulates Gab2, and to investigate whether this mechanism is impaired in human cancers, leading to enhanced Gab2 signalling. The research will provide important information regarding how growth factor signals are transmitted inside cells, and may identify a new cancer-causing gene.

Funded Activity Details

Start Date: 01-01-2003

End Date: 01-01-2003

Funding Scheme: NHMRC Project Grants

Funding Amount: $141,750.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oncology And Carcinogenesis

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Breast cancer | EGF receptor family kinases | ErbB2-mediated cell signalling | Glioblastoma | Head and neck cancer | Ovarian cancer | breast cancer | oncogene | protein tyrosine kinase

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