Transfer of glutamine between astrocytes and neurons

Funded Activity Summary

Brain tissue is comprised of only a few different cell types. These are classified as neurons, glial cells, and cells of mesodermal origin. Glial cells are the most abundant cell type in the brain and include cells known as astrocytes. There is increasing evidence that astrocytes are actively involved in the maintenance and regulation of neuronal function. This study focuses on the mechanisms by which astrocytes supply neurons with precursors for the formation of signalling molecules (neurotransmitters) released from neurons in the transmission of nerve impulses. It will establish how these processes are controlled and also try to develop inhibitors that interfere with this process . The project tries to elucidate whether astrocytes actively regulate neuronal functions by regulating precursor supply. The work will make a significant contribution to our understanding of how astrocytes regulate neuronal activity, a process that may be critical in conditions such as stroke and epilepsy. A better understanding of the physiology of astrocytes might lead to improved treatments for these disturbances of brain function.

Funded Activity Details

Start Date: 01-01-2003

End Date: 01-01-2005

Funding Scheme: NHMRC Project Grants

Funding Amount: $255,500.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Membrane Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Astrocytes | Epilepsy | Glutamine | Hepatic encephalopathy | Neurochemistry | Stroke/Ischemia | Transporter

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