Obesity Induced by Chronic High-Energy Diet: Central Influences in Development and Prevention

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/213104

Funding Status
Closed

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Funded Activity Summary

This project is about the study of central regulation of energy balance contributing to prevention or development of chronic high-energy diet-induced obesity. Obesity is a major predisposing factor for a variety of life threatening diseases such as type II diabetes, hypertension, and coronary heart disease with their enormous costs both socially and economically. Development of human obesity and its related metabolic disorders generally develops over a long period and eventually becomes a chronic condition. Generally, chronic consumption of high-energy food in excess of expenditure leads to excessive fat accumulation and promotes the development of obesity. However, under these conditions, some individuals become obese, while others remain lean indicating that variation in susceptibility is an important determinant of the development of obesity. It is apparent that those individuals resistant to obesity have a more effective defence system against excessive fat accumulation. Using the animal models developed in our laboratory, the proposed research aims to search for the differences in the central regulation between the mice resistant or susceptible to the development of obesity. The outcomes we expect to achieve include: 1) better understanding of central factors controlling energy balance, 2) clarification of the central factors responsible for dysregulation of this system by chronic consumption of a high-energy diet, and 3) identification of those factors contributing to prevention against such dysregulation. Further, according to our previous study [XFH1, 2, 3], we propose to use the drugs targeting on the specific receptor subtypes to test reversibility of chronic high energy diet-induced obesity.

Funded Activity Details

Start Date: 01-01-2002

End Date: 01-01-2004

Funding Scheme: NHMRC Project Grants

Funding Amount: $221,210.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical infection agents (incl. prions)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Brain | Hyperleptinemia, hyperlipidimia and hyperglycemia | Leptin resistance | Moleculoneurobiology | Neuropeptide | Obesity | Obesity and its related metabolic disorders | Treatment of chronic high-energy diet-induced obesity | mRNA expression

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