Role of Flavonoids from Phytomedicines in Herb-Drug Interactions Mediated by P-glycoprotein

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/211167

Funding Status
Closed

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Funded Activity Summary

The herbal therapeutics St John's wort and Ginkgo biloba are used by cancer patients to alleviate symptoms of psychic disturbances associated with their condition. The possibility of interactions between flavonoid components of these herbs and anticancer treatment will be examined. Resistance to cancer chemotherapy often develops due to overexpression of the drug transporter P-glycoprotein (P-gp). Investigation of the interaction of the flavonoid components of herbal preparations and P-gp will establish whether the flavonoids alter the outcome of chemotherapy in resistant cancers in the short term. We will also examine whether exposure to flavonoids in herbal medicines and diets rich in flavonoids from fruit and vegetables affects development and progress of multidrug resistance over the long term.

Funded Activity Details

Start Date: 01-01-2002

End Date: 01-01-2004

Funding Scheme: NHMRC Project Grants

Funding Amount: $210,990.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biochemistry - lipids

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

P-glycoprotein | anxiety / depression | cancer biology | cancer treatment | drug interactions | multidrug resistance

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