Optimal duration of neoadjuvant androgen deprivation therapy in localised prostate cancer

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/209801

Funding Status
Closed

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Funded Activity Summary

Each year approximately 8000 men in Australia and New Zealand develop prostate cancer which has not spread widely and which is amenable to attempted cure by surgery or radiation. Prostate cancer depends for its growth on the male hormone, testosterone, which circulates in the blood. As a result treatment which reduces testosterone level ('androgen deprivation' [AD] therapy) can produce shrinkage of prostate cancer. In fact AD has caused temporary but valued relief to millions of men with cancer of the prostate that has spread throughout the body for the last five decades, worldwide. It remains uncertain however whether AD administered before surgery or radiation will benefit any of the 8000 men each year who develop localised cancer by shrinking the cancer first. In 1996 a trial involving 800 men across Australia and New Zealand commenced under the auspices of the Trans-Tasman Radiation Oncology Group (TROG) to answer the questions: 1 - Does either 3 or 6 months AD prior to radiotherapy reduce the chances of recurrence of the cancer after radiotherapy? 2 - Does such therapy reduce the volume of tissue requiring radiotherapy and hence the chances of long term side effects after radiotherapy? This grant will support collection of follow-up information from the trial and hence answers to the questions asked.

Funded Activity Details

Start Date: 01-01-2002

End Date: 01-01-2006

Funding Scheme: NHMRC Project Grants

Funding Amount: $275,000.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oncology And Carcinogenesis

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Endocrine therapy | Prostate Cancer | Prostate carcinoma/RT(radiotherapy) | Quality of life | Radiotherapy | Radiotherapy/AE (adverse effects) | Randomised controlled trial | Survival rate | Therapy of prostate cancer

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