HERG K+ channels: Molecular basis of gating

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/209547

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

The rhythm of the normal heart beat is controlled by electrical signals mediated by the flow of ions. The movement of ions across heart cell membranes is predominantly mediated by ion channel proteins. One of these proteins, called HERG, has some very unusual properties that make it well suited for suppressing abnormal heart beats. We propose to undertake a detailed investigation of the mechanisms by which HERG channels open and close. The results will provided a greater understanding of how HERG channels work and how altered function of HERG channels in patients with heart disease leads to an increased risk of abnormal heart rhythms and sudden cardiac death.

Funded Activity Details

Start Date: 01-01-2002

End Date: 01-01-2004

Funding Scheme: NHMRC Project Grants

Funding Amount: $436,650.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biophysics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Long QT syndrome | arrhythmias | cardiac electrophysiology | potassium channels | pro-arhythmia | site-directed mutagenesis | sudden cardiac death

Related Links