NEPHROTOXICITY OF ANGIOTENSIN INHIBITION DURING RENAL DEVELOPMENT

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/208961

Funding Status
Closed

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Funded Activity Summary

Renal dysplasia and renal cystic disease remain significant clinical problems in the paediatric population. Initial animal experiments have demonstrated that inhibiting the renal vasoactive peptide angiotensin during development results in a form of medullary cystic disease. The experiments in this project are aimed at understanding the specific roles and interactions that angiotensin plays in renal development, particularly in development of the distal nephron, the vasculature and the renal pelvis. Importantly the time course of growth and differentiation of these structures varies and the time course of inactivation of angiotensin may result in different malformations. Information from these studies will allow us to understand how clinical problems can arise when angiotensin is absent or other players modify its action. Such situations can arise in humans through sporadic genetic mutations that may well not manifest in widespread clinical abnormalities.

Funded Activity Details

Start Date: 01-01-2002

End Date: 01-01-2004

Funding Scheme: NHMRC Project Grants

Funding Amount: $210,990.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Public health nutrition

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

ANGIOTENSIN | ANGIOTENSIN RECEPTORS | BRADYKININ | HYDRONEPHROSIS | KIDNEY DEVELOPMENT | RENAL DISEASE | RENAL DYSPLASIA | RENAL PELVIS | RENAL VASCULAR HYPERTROPHY | URINARY CONCENTRATING IMPAIRMENT

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