The role of protease-activated receptor-2 in regulation of bone metabolism

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/208960

Funding Status
Closed

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Funded Activity Summary

Many diseases of bones, such as osteoporosis and delayed fracture repair, result from the abnormal function of bone cells. Factors regulating bone cell function are, therefore, important in maintaining a healthy skeleton, as well as in the skeleton's response to disease. We have recently demonstrated the presence of a receptor called PAR-2 on bone-forming cells. We have also shown that activation of PAR-2 inhibits the development of bone-resorbing cells (osteoclasts) in response to hormones. We plan to investigate the mechanism of this effect, as well as to identify how PAR-2 activation modulates other responses of bone cells to hormones. Molecules that activate PAR-2 are present in bone in certain disease situations, but it is not known what activates PAR-2 in bone under normal conditions. We will identify physiological activators of PAR-2 within bone.

Funded Activity Details

Start Date: 01-01-2002

End Date: 01-01-2003

Funding Scheme: NHMRC Project Grants

Funding Amount: $216,100.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutritional science

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Fracture repair | Mastocytosis | Osteoblast | Osteoclast | Osteoporosis | Parathyroid hormone | Periodontal disease | Prostaglandin | Protease-activated receptor | Rheumatoid arthritis

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