Tapasin and Major Histocompatibility Complex Class I Antigen Presentation

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/204702

Funding Status
Closed

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Funded Activity Summary

An effective T cell response (cellular immune response) to infections is vital to a functional immune system. Normally, proteins are cleaved into small molecules called peptides and these peptides are in turn presented by Major Histocompatibility Complex molecules to T cells. However, we have only partial understanding of what determines the choice of peptides that are finally presented to T cells. Recent research suggests that a molecule called tapasin may also influence the choice of peptides. This research proposal aims to examine the role of tapasin in this regard. A thorough understanding of the basic principles of peptide presentation to T cells is crucial to the design of effective vaccines. Furthermore it will also broaden our understanding of immunological responses to cancer, autoimmune diseases and infections.

Funded Activity Details

Start Date: 01-01-2002

End Date: 01-01-2004

Funding Scheme: NHMRC Project Grants

Funding Amount: $226,650.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical chemistry (incl. diagnostics)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Antigen Presentation | Major Histocompatibility Complex Class I | Optimization of MHC-class I peptide ligands | Tapasin | Thermostability of MHC-class I complexes | autoimmunity | immunity to infection | tumour immunology | vaccine immunology | viral infections

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