Innate immune sensing of Proteotoxic Stress

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/2003756

Funding Status
Status not available

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Funded Activity Summary

Cells recycle old components using a system called the proteasome. Some people are born without parts of the proteasome, and they suffer from a disease associated with inflammation. We have identified the molecular trigger for this inflammation. Our findings are also relevant for patients being treated with proteasome inhibitors. In some of these diseases, such as lupus, inflammation can be a side-effect of proteasome inhibitor therapy, and we can now reduce this and make the treatments safer.

Funded Activity Details

Start Date: 01-01-2020

End Date: End date not available

Funding Scheme: Ideas Grants

Funding Amount: $501,390.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

lupus | pattern recognition | proteasome | stress response

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