A new mechanism of tissue fibrosis - a small peptide regulator of the TGF-beta1/Smad pathway

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/2003019

Funding Status
Status not available

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Funded Activity Summary

Progressive scarring, or fibrosis, of organs leads to their loss of function. Fibrotic diseases are devastating to both the individual and our community and we lack effective therapies. We have identified a small protein, named SPRF, which represents a new mechanism in tissue fibrosis. These studies will examine the role of the SRPF protein in models of kidney, heart and lung fibrosis and its underlying mechanism of action. We will also test a therapy based on inhibiting SPRF function.

Funded Activity Details

Start Date: 01-01-2020

End Date: End date not available

Funding Scheme: Ideas Grants

Funding Amount: $768,757.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

diabetic nephropathy | fibrosis | glomerulosclerosis | transforming growth factor beta (tgf-beta)

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