Deadly commute - targeting the trafficking mechanisms that licence inflammatory cell death

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/2002965

Funding Status
Status not available

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Funded Activity Summary

MLKL is a protein naturally found inside cells. MLKL is activated by inflammation. Once activated, MLKL relocates to the outer periphery of cells and kills them. Gut cells are especially vulnerable to death-by-MLKL and this problem causes Inflammatory Bowel Disease. Using cutting edge microscopy, we have discovered how MLKL moves to the periphery of cells prior to killing them. We will test if blocking this movement of MLKL to the cell periphery stops gut death and Inflammatory Bowel Disease.

Funded Activity Details

Start Date: 01-01-2020

End Date: 01-01-2023

Funding Scheme: Ideas Grants

Funding Amount: $774,544.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cell death | inflammatory bowel disease (ibd) | tissue necrosis factor (tnf) | trafficking

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