Vascular changes are a key contributor to and novel drug target for interferon-alpha induced neurological disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/2001543

Funding Status
Status not available

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Funded Activity Summary

Type I interferons (IFN-Is) contribute to wide range of neurological diseases including ageing and neurodegeneration. At its extreme IFN-I-mediated neurodegeneration is known as 'interferonopathy'. The mechanisms of how IFN-Is drive disease are unclear, making causal treatment difficult. We have recently uncovered ground-breaking evidence that abnormal blood vessels are a key contributor to the disease. Here, we will investigate novel treatment targets for patients with interferonopathies.

Funded Activity Details

Start Date: 01-01-2020

End Date: End date not available

Funding Scheme: Ideas Grants

Funding Amount: $1,245,401.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

central nervous system (cns) diseases | endothelial cells | interferon (ifn) | transgenic model

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